Neutrophils mediate the influence of catecholamines on inflammation
Excessive or dysregulated neutrophil activation can lead to uncontrolled inflammation and tissue damage and thus contribute to the pathogenesis of acute and chronic inflammatory diseases, Understanding the regulation of neutrophil activation and recruitment is therefore of paramount importance. There is accumulating evidence that neurotransmitters like catecholamines act as immunomodulators to control inflammation. In this project, we therefore aim to decipher the catecholamine-neutrophil axis, investigating de novo synthesis of catecholamines as well as their degradation and transport by neutrophils, and evaluating the influence of these interactions on chronic and acute cardiovascular and thrombotic diseases.
Team
Publications
Anti-Rubella IgG Serum Levels Predict Risk for SARS-CoV-2 Breakthrough Infections.Hollstein, M. M.; Dierks, S.; Schön, M. P.; Groß, U.; Thiele, K.; Leha, A.; Zautner, A. E.; Fischer, A.; Erpenbeck, L.; Schnelle, M.
2024 Allergy
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Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relayMihlan, M.; Wissmann, S.; Gavrilov, A.; Kaltenbach, L.; Britz, M.; Franke, K.; Hummel, B.; Imle, A.; Suzuki, R.; Stecher, M.; Glaser, K. M.; Lorentz, A.; Carmeliet, P.; Yokomizo, T.; Hilgendorf, I.; Sawarkar, R.; Diz-Muñoz, A.; Buescher, J. M.; Mittler, G.; Maurer, M.; Krause, K.; Babina, M.; Erpenbeck, L.; Frank, M.; Rambold, A. S.; Lämmermann, T.
2024 Cell
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrology Dialysis Transplantation
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Targeting Neutrophil Extracellular Traps (NETs) Ameliorates Inflammation in Murine Psoriasiform DermatitisHollstein, M. M.; Manzke, V.; Scheidmann, S. E. F.; Schrenker, S.; Schaffrinski, M.; Neubert, E.; Kramer, D.; Raker, V. K.; Schön, M. P.; Erpenbeck, L.
2023 Journal of Dermatological Science
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Expansion microscopy of neutrophil nuclear structure and extracellular trapsHolsapple, J. S.; Schnitzler, L.; Rusch, L.; Baldeweg, T. H.; Neubert, E.; Kruss, S.; Erpenbeck, L.
2022 Biophysical Reports
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