Cytosolic S100A8/A9 Promotes Ca2+ Supply at LFA-1 Adhesion Clusters during Neutrophil RecruitmentNapoli, M.; Immler, R.; Rohwedder, I.; Lupperger, V.; Pfabe, J.; Gonzalez Pisfil, M.; Yevtushenko, A.; Vogl, T.; Roth, J.; Salvermoser, M.; Dietzel, S.; Slak Rupnik, M.; Marr, C.; Walzog, B.; Sperandio, M.; Pruenster, M.
2024 Elife
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Mediterranean Diet, Neutrophil Count, and Carotid Intima-Media Thickness in Secondary Prevention: The CORDIOPREV StudyBoughanem, H.; Torres-Peña, J. D.; Arenas-de Larriva, A. P.; Romero-Cabrera, J. L.; Gómez-Luna, P.; Martín-Piedra, L.; Rodríguez-Cantalejo, F.; Tinahones, F. J.; Yubero Serrano, E. M.; Soehnlein, O.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J.
2024 Eur Heart J
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Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence: Results From the CORDIOPREV StudyBoughanem, H.; de Larriva, A. P. A.; Camargo, A.; Torres-Peña, J. D.; Ojeda-Rodriguez, A.; Alcala-Diaz, J. F.; Romero-Cabrera, J. L.; Rangel-Zuñiga, O. A.; Rodríguez-Cantalejo, F.; Soehnlein, O.; Macias-Gonzalez, M.; Tinahones, F. J.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J.
2024 The Journal of Clinical Endocrinology & Metabolism
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Intermittent High-Fat Diet: Atherosclerosis Progression by Neutrophil ReprogrammingHerrero-Cervera, A.; Chevre, R.; Soehnlein, O.
2024 Sig Transduct Target Ther
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Glutamine Modulates Neutrophil Recruitment and Effector Functions during Sterile InflammationHellenthal, K. E. M.; Thomas, K.; Ludwig, N.; Cappenberg, A.; Schemmelmann, L.; Tekath, T.; Margraf, A.; Mersmann, S.; Henke, K.; Rossaint, J.; Zarbock, A.; Amini, W.
2024 J Leukoc Biol
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Redistribution of PU.1 Partner Transcription Factor RUNX1 Binding Secures Cell Survival during Leukemogenesis.Bender, A.; Boydere, F.; Jayavelu, A. K.; Tibello, A.; König, T.; Aleth, H.; Meyer Zu Hörste, G.; Vogl, T.; Rosenbauer, F.
2024 EMBO J
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Novel Multiphoton Intravital Imaging Enables Real-Time Study of Helicobacter Pylori Interaction with Neutrophils and Macrophages in the Mouse StomachIshikawa-Ankerhold, H.; Busch, B.; Bader, A.; Maier-Begandt, D.; Dionisio, F.; Namineni, S.; Vladymyrov, M.; Harrison, U.; van den Heuvel, D.; Tomas, L.; Walzog, B.; Massberg, S.; Schulz, C.; Haas, R.
2024 PLoS Pathog
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Proteomic Characterization of 1,000 Human and Murine Neutrophils Freshly Isolated from Blood and Sites of Sterile Inflammation.Ghosh, S.; Tuz, A. A.; Stenzel, M.; Singh, V.; Richter, M.; Soehnlein, O.; Lange, E.; Heyer, R.; Cibir, Z.; Beer, A.; Jung, M.; Nagel, D.; Hermann, D. M.; Hasenberg, A.; Grüneboom, A.; Sickmann, A.; Gunzer, M.
2024 Mol Cell Proteomics
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Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signallingHermann, D. M.; Peruzzotti-Jametti, L.; Giebel, B.; Pluchino, S.
2024 Brain
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Arterial Specification Precedes Microvascular Restitution in the Peri-Infarct Cortex That Is Driven by Small MicrovesselsHagemann, N.; Qi, Y.; Mohamud Yusuf, A.; Li, A.; Zhang, X.; Spangenberg, P.; Squire, A.; Doeppner, T. R.; Jin, F.; Zhao, S.; Chen, J.; Mosig, A.; Gunzer, M.; Hermann, D. M. .
2024 J Cereb Blood Flow Metab
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Neonatal neutrophils exhibit reduced NLRP3 inflammasome activationWackerbarth, L. M.; Seifert, S. B.; Napoli, M.; Rohwedder, I.; Vogl, T.; Scheiermann, C.; Kolben, T.; Nussbaum, C.; Pruenster, M.; Immler, R.; Sperandio, M.
2024 J Leukoc Biol
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Anti-Rubella IgG Serum Levels Predict Risk for SARS-CoV-2 Breakthrough Infections.Hollstein, M. M.; Dierks, S.; Schön, M. P.; Groß, U.; Thiele, K.; Leha, A.; Zautner, A. E.; Fischer, A.; Erpenbeck, L.; Schnelle, M.
2024 Allergy
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Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profilesPajonczyk, D.; Sternschulte, M. F.; Soehnlein, O.; Bermudez, M.; Raabe, C. A.; Rescher, U.
2024 British Journal of Pharmacology
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Inhibition of Complement Factor C5a or C5aR for Cholesterol Crystal Embolism-Related Vascular Thrombosis with Microvascular Injury and Its Consequences.Zhao, D.; Han, C.; Mammadova-Bach, E.; Watanabe-Kusunoki, K.; Honda, T. S. B.; Li, Y.; Li, C.; Li, Q.; Long, H.; Lyubenov, L.; Shi, C.; Santovito, D.; Weber, C.; Boor, P.; Droste, P.; Parikh, S.; Shapiro, J.; Chiara, L. D.; Carangelo, G.; Romagnani, P.; Klussmann, S.; Vater, A.; Anders, H.-J.
2024 Kidney International
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DNA-Sensing Inflammasomes Cause Recurrent Atherosclerotic StrokeCao, J.; Roth, S.; Zhang, S.; Kopczak, A.; Mami, S.; Asare, Y.; Georgakis, M. K.; Messerer, D.; Horn, A.; Shemer, R.; Jacqmarcq, C.; Picot, A.; Green, J. P.; Schlegl, C.; Li, X.; Tomas, L.; Dutsch, A.; Liman, T. G.; Endres, M.; Wernsdorf, S. R.; Fürle, C.; Carofiglio, O.; Zhu, J.; Brough, D.; Veit Hornung; Dichgans, M.; Vivien, D.; Schulz, C.; Dor, Y.; Tiedt, S.; Sager, H. B.; Grosse, G. M.; Liesz, A. D.
2024 Nature
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Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relayMihlan, M.; Wissmann, S.; Gavrilov, A.; Kaltenbach, L.; Britz, M.; Franke, K.; Hummel, B.; Imle, A.; Suzuki, R.; Stecher, M.; Glaser, K. M.; Lorentz, A.; Carmeliet, P.; Yokomizo, T.; Hilgendorf, I.; Sawarkar, R.; Diz-Muñoz, A.; Buescher, J. M.; Mittler, G.; Maurer, M.; Krause, K.; Babina, M.; Erpenbeck, L.; Frank, M.; Rambold, A. S.; Lämmermann, T.
2024 Cell
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Formyl Peptide Receptor 2 (FPR2) Regulates Dendritic Cell Metabolism and Th17 Cell Differentiation during NeuroinflammationLim, J.-H.; Neuwirth, A.; Chung, K.-J.; Grossklaus, S.; Soehnlein, O.; Hajishengallis, G.; Chavakis, T.
2024 Front. Immunol
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Innate Immune Memory after Brain Injury Drives Inflammatory Cardiac DysfunctionSimats, A.; Zhang, S.; Messerer, D.; Chong, F.; Beşkardeş, S.; Chivukula, A. S.; Cao, J.; Besson-Girard, S.; Montellano, F. A.; Morbach, C.; Carofiglio, O.; Ricci, A.; Roth, S.; Llovera, G.; Singh, R.; Chen, Y.; Filser, S.; Plesnila, N.; Braun, C.; Spitzer, H.; Gokce, O.; Dichgans, M.; Heuschmann, P. U.; Hatakeyama, K.; Beltrán, E.; Clauss, S.; Bonev, B.; Schulz, C.; Liesz, A.
2024 Cell
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Functional Multi-Organelle Units Control Inflammatory Lipid Metabolism of MacrophagesZimmermann, J. A.; Lucht, K.; Stecher, M.; Badhan, C.; Glaser, K. M.; Epple, M. W.; Koch, L. R.; Deboutte, W.; Manke, T.; Ebnet, K.; Brinkmann, F.; Fehler, O.; Vogl, T.; Schuster, E.-M.; Bremser, A.; Buescher, J. M.; Rambold, A. S.
2024 Nat Cell Biol
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Neuro-Immune Crosstalk in Hematopoiesis, Inflammation, and RepairAkinyemi, D. E.; Chevre, R.; Soehnlein, O.
2024 Trends in Immunology
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Central Trained Immunity and Its Impact on Chronic Inflammatory and Autoimmune DiseasesHajishengallis, G.; Chavakis, T.
2024 Journal of Allergy and Clinical Immunology
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Neutrophils and Extracellular Traps in Crystal-Associated DiseasesMa, Q.; Steiger, S.
2024 Trends Mol Med
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Targeting Extranuclear Histones to Alleviate Acute and Chronic Inflammation.Nicolaes, G. A. F.; Soehnlein, O.
2024 Trends Pharmacol Sci
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Clonal Hematopoiesis Driven by Mutated DNMT3A Promotes Inflammatory Bone LossWang, H.; Divaris, K.; Pan, B.; Li, X.; Lim, J.-H.; Saha, G.; Barovic, M.; Giannakou, D.; Korostoff, J. M.; Bing, Y.; Sen, S.; Moss, K.; Wu, D.; Beck, J. D.; Ballantyne, C. M.; Natarajan, P.; North, K. E.; Netea, M. G.; Chavakis, T.*; Hajishengallis, G*. * equal contribution
2024 Cell
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Resident and Recruited Macrophages Differentially Contribute to Cardiac Healing after Myocardial IschemiaWeinberger, T.; Denise, M.; Joppich, M.; Fischer, M.; Garcia Rodriguez, C.; Kumaraswami, K.; Wimmler, V.; Ablinger, S.; Räuber, S.; Fang, J.; Liu, L.; Liu, W. H.; Winterhalter, J.; Lichti, J.; Thomas, L.; Esfandyari, D.; Percin, G.; Matin, S.; Hidalgo, A.; Waskow, C.; Engelhardt, S.; Todica, A.; Zimmer, R.; Pridans, C.; Gomez Perdiguero, E.; Schulz, C.
2024 eLife
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Lack of Formyl-Peptide Receptor 1 Mitigates Atherosclerosis in Hyperlipidemic Mice |
CCR3-Dependent Eosinophil Recruitment Is Regulated by Sialyltransferase ST3Gal-IV.Immler, R.; Nussbaumer, K.; Doerner, A.; El Bounkari, O.; Huber, S.; Abisch, J.; Napoli, M.; Schmidt, S.; Margraf, A.; Pruenster, M.; Rohwedder, I.; Lange-Sperandio, B.; Mall, M. A.; de Jong, R.; Ohnmacht, C.; Bernhagen, J.; Voehringer, D.; Marth, J. D.; Frommhold, D.; Sperandio, M.
2024 Proceedings of the National Academy of Sciences
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Gasdermin D drives focal Crystalline Thrombotic Microangiopathy by accelerating Immunothrombosis and NecroinflammationWatanabe-Kusunoki, K.; Li, C.; Bandeira Honda, T. S.; Zhao, D.; Kusunoki, Y.; Ku, J.; Long, H.; Klaus, M.; Han, C.; Braun, A.; Mammadova-Bach, E.; Linkermann, A.; Van Avondt, K.; Richter, M.; Soehnlein, O.; Linder, M. I.; Klein, C.; Steiger, S.; Anders, H.-J.
2024 Blood
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Stroke and Myocardial Infarction Induce Neutrophil Extracellular Trap Release Disrupting Lymphoid Organ Structure and Immunoglobulin SecretionTuz, A. A.; Ghosh, S.; Karsch, L.; Ttoouli, D.; Sata, S. P.; Ulusoy, Ö.; Kraus, A.; Hoerenbaum, N.; Wolf, J.-N.; Lohmann, S.; Zwirnlein, F.; Kaygusuz, V.; Lakovic, V.; Tummes, H.-L.; Beer, A.; Gallert, M.; Thiebes, S.; Qefalia, A.; Cibir, Z.; Antler, M.; Korste, S.; Haj Yehia, E.; Michel, L.; Rassaf, T.; Kaltwasser, B.; Abdelrahman, H.; Mohamud Yusuf, A.; Wang, C.; Yin, D.; Haeusler, L.; Lueong, S.; Richter, M.; Engel, D. R.; Stenzel, M.; Soehnlein, O.; Frank, B.; Solo-Nomenjanahary, M.; Ho-Tin-Noé, B.; Siveke, J. T.; Totzeck, M.; Hoffmann, D.; Grüneboom, A.; Hagemann, N.; Hasenberg, A.; Desilles, J.-P.; Mazighi, M.; Sickmann, A.; Chen, J.; Hermann, D. M.; Gunzer, M.; Singh, V.
2024 Nat Cardiovasc Res
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Scientific Advances in Understanding the Pathogenesis, Diagnosis, and Prevention of Urinary Tract Infection in the Past 10 YearsEngel, D. R.; Wagenlehner, F. M. E.; Shevchuk, O.
2024 Infect Dis Clin North Am
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Novel Possibilities for Targeting Neutrophils in CancerSilvestre-Roig, C.; Kalafati, L.; Chavakis, T.
2024 Sig Transduct Target Ther
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Cyclophilin A Is a Ligand for RAGE in Thrombo-InflammationSeizer, P.; von Ungern-Sternberg, S. N. I.; Haug, V.; Dicenta, V.; Rosa, A.; Butt, E.; Nöthel, M.; Rohlfing, A.-K.; Sigle, M.; Nawroth, P. P.; Nussbaum, C.; Sperandio, M.; Kusch, C.; Meub, M.; Sauer, M.; Münzer, P.; Bieber, K.; Stanger, A.; Mack, A. F.; Huber, R.; Brand, K.; Lehners, M.; Feil, R.; Poso, A.; Krutzke, K.; Schäffer, T. E.; Nieswandt, B.; Borst, O.; May, A. E.; Zernecke, A.; Gawaz, M.; Heinzmann, D.
2024 Cardiovasc Res
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Circadian Clock and HypoxiaSartor, F.; Ferrero-Bordera, B.; Haspel, J.; Sperandio, M.; Holloway, P. M.; Merrow, M.
2024 Circulation Research
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Controversies associated with the identification of the true origins of human neutrophilsSilvestre-Roig, C.; Brandau, S.
2024 Journal of Leukocyte Biology
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Potent induction of trained immunity by Saccharomyces cerevisiae β-glucansVuscan, P.; Kischkel, B.; Hatzioannou, A.; Markaki, E.; Sarlea, A.; Tintoré, M.; Cuñé, J.; Verginis, P.; de Lecea, C.; Chavakis, T.; Joosten, L. A. B.; Netea, M. G.
2024 Frontiers in Immunology
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CD38 promotes hematopoietic stem cell dormancyIbneeva, L.; Singh, S. P.; Sinha, A.; Eski, S. E.; Wehner, R.; Rupp, L.; Kovtun, I.; Pérez-Valencia, J. A.; Gerbaulet, A.; Reinhardt, S.; Wobus, M.; von Bonin, M.; Sancho, J.; Lund, F.; Dahl, A.; Schmitz, M.; Bornhäuser, M.; Chavakis, T.; Wielockx, B.; Grinenko, T.
2024 PLoS Biol
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ComplexEye: a multi-lens array microscope for high-throughput cell migration analysis |
Generation of Complex Bone Marrow Organoids from Human Induced Pluripotent Stem Cells.Frenz-Wiessner, S.; Fairley, S. D.; Buser, M.; Goek, I.; Salewskij, K.; Jonsson, G.; Illig, D.; zu Putlitz, B.; Petersheim, D.; Li, Y.; Chen, P.-H.; Kalauz, M.; Conca, R.; Sterr, M.; Geuder, J.; Mizoguchi, Y.; Megens, R. T. A.; Linder, M. I.; Kotlarz, D.; Rudelius, M.; Penninger, J. M.; Marr, C.; Klein, C.
2024 Nat Methods
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Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet MicroscopyNina Hagemann, Yachao Qi, Ayan Mohamud Yusuf, AnRan Li, Anthony Squire, Tobias Tertel, Bernd Giebel, Peter Ludewig, Philippa Spangenberg, Jianxu Chen, Axel Mosig, Matthias Gunzer and Dirk M. Hermann
2024 Arteriosclerosis, Thrombosis, and Vascular Biology
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Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammationArribas, V.; Onetti, Y.; Ramiro-Pareta, M.; Villacampa, P.; Beck, H.; Alberola, M.; Esteve-Codina, A.; Merkel, A.; Sperandio, M.; Martínez-Estrada, O. M.; Schmid, B.; Montanez, E.
2024 JCI Insight
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An IL-10/DEL-1 Axis Supports Granulopoiesis and Survival from Sepsis in Early LifeVergadi, E.; Kolliniati, O.; Lapi, I.; Ieronymaki, E.; Lyroni, K.; Alexaki, V. I.; Diamantaki, E.; Vaporidi, K.; Hatzidaki, E.; Papadaki, H. A.; Galanakis, E.; Hajishengallis, G.; Chavakis, T.; Tsatsanis, C.
2024 Nat Commun
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A Novel Macrolide-Del-1 Axis to Regenerate Bone in Old AgeSirisereephap, K.; Tamura, H.; Lim, J.-H.; Surboyo, M. D. C.; Isono, T.; Hiyoshi, T.; Rosenkranz, A. L.; Sato-Yamada, Y.; Domon, H.; Ikeda, A.; Hirose, T.; Sunazuka, T.; Yoshiba, N.; Okada, H.; Terao, Y.; Maeda, T.; Tabeta, K.; Chavakis, T.; Hajishengallis, G.; Maekawa, T.
2024 iScience
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Mononuclear Myeloid Cells Can Shape Neutrophils in Brain Tumors. |
Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donorsPettinella, F.; Mariotti, B.; Lattanzi, C.; Bruderek, K.; Donini, M.; Costa, S.; Marini, O.; Iannoto, G.; Gasperini, S.; Caveggion, E.; Castellucci, M.; Calzetti, F.; Bianchetto-Aguilera, F.; Gardiman, E.; Giani, M.; Dusi, S.; Cantini, M.; Vassanelli, A.; Pavone, D.; Milella, M.; Pilotto, S.; Biondani, P.; Höing, B.; Schleupner, M. C.; Hussain, T.; Hadaschik, B.; Kaspar, C.; Visco, C.; Tecchio, C.; Koenderman, L.; Bazzoni, F.; Tamassia, N.; Brandau, S.; Cassatella, M. A.; Scapini, P.
2024 CR Med
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Modulating microglia to enhance neuroplasticity for restoring brain function after strokeLiu, Z.; Hermann, D. M.; Dzyubenko, E.; Cao, G.; Cao, X.
2023 Front. Cell. Neurosci.
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Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post strokeDzyubenko, E.; Willig, K. I.; Yin, D.; Sardari, M.; Tokmak, E.; Labus, P.; Schmermund, B.; Hermann, D. M.
2023 Journal of Biomedical Science
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Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhagesYin, D.; Wang, C.; Qi, Y.; Wang, Y.-C.; Hagemann, N.; Mohamud Yusuf, A.; Dzyubenko, E.; Kaltwasser, B.; Tertel, T.; Giebel, B.; Gunzer, M.; Popa-Wagner, A.; Doeppner, T. R.; Hermann, D. M.
2023 J Neuroinflammation
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Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD MiceSchiffmann, D.; Lampkemeyer, V.; Lindner, M.; Fleck, A.-K.; Koch, K.; Eschborn, M.; Liebmann, M.; Strecker, J.-K.; Minnerup, J.; Wiendl, H.; Klotz, L.
2023 International Journal of Molecular Sciences
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrology Dialysis Transplantation
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ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysisCibir, Z.; Hassel, J.; Sonneck, J.; Kowitz, L.; Beer, A.; Kraus, A.; Hallekamp, G.; Rosenkranz, M.; Raffelberg, P.; Olfen, S.; Smilowski, K.; Burkard, R.; Helfrich, I.; Tuz, A. A.; Singh, V.; Ghosh, S.; Sickmann, A.; Klebl, A.-K.; Eickhoff, J. E.; Klebl, B.; Seidl, K.; Chen, J.; Grabmaier, A.; Viga, R.; Gunzer, M.
2023 Nature Communications
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HPV-Associated Head and Neck Cancer Is Characterized by Distinct Profiles of CD8+ T Cells and Myeloid-Derived Suppressor CellsKansy, B. A.; Wehrs, T. P.; Bruderek, K.; Si, Y.; Ludwig, S.; Droege, F.; Hasskamp, P.; Henkel, U.; Dominas, N.; Hoffmann, T. K.; Horn, P. A.; Schuler, M.; Gauler, T. C.; Lindemann, M.; Lang, S.; Bankfalvi, A.; Brandau, S.
2023 Cancer Immunol Immunother
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Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease |
Sellhi neutrophils: a key to triumph in cancer therapyPylaeva, E.; Jablonska, J.
2023 Signal Transduction and Targeted Therapy
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E-Selectin-Mediated Rapid NLRP3 Inflammasome Activation Regulates S100A8/S100A9 Release from Neutrophils via Transient Gasdermin D Pore Formation.Pruenster, M.; Immler, R.; Roth, J.; Kuchler, T.; Bromberger, T.; Napoli, M.; Nussbaumer, K.; Rohwedder, I.; Wackerbarth, L. M.; Piantoni, C.; Hennis, K.; Fink, D.; Kallabis, S.; Schroll, T.; Masgrau-Alsina, S.; Budke, A.; Liu, W.; Vestweber, D.; Wahl-Schott, C.; Roth, J.; Meissner, F.; Moser, M.; Vogl, T.; Hornung, V.; Broz, P.; Sperandio, M.
2023 Nat Immunol
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Nuclease Activity and Protein A Release of Staphylococcus Aureus Clinical Isolates Determine the Virulence in a Murine Model of Acute Lung Infection.Ludwig, N.; Thörner-van Almsick, J.; Mersmann, S.; Bardel, B.; Niemann, S.; Chasan, A. I.; Schäfers, M.; Margraf, A.; Rossaint, J.; Kahl, B. C.; Zarbock, A.; Block, H.
2023 Front Immunol
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Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infectionZec, K.; Thiebes, S.; Bottek, J.; Siemes, D.; Spangenberg, P.; Trieu, D. V.; Kirstein, N.; Subramaniam, N.; Christ, R.; Klein, D.; Jendrossek, V.; Loose, M.; Wagenlehner, F.; Jablonska, J.; Bracht, T.; Sitek, B.; Budeus, B.; Klein-Hitpass, L.; Theegarten, D.; Shevchuk, O.; Engel, D. R.
2023 Front. Immunol.
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Externalized Histones Fuel Pulmonary Fibrosis via a Platelet-Macrophage Circuit of TGFβ1 and IL-27Riehl, D. R.; Sharma, A.; Roewe, J.; Murke, F.; Ruppert, C.; Eming, S. A.; Bopp, T.; Kleinert, H.; Radsak, M. P.; Colucci, G.; Subramaniam, S.; Reinhardt, C.; Giebel, B.; Prinz, I.; Guenther, A.; Strand, D.; Gunzer, M.; Waisman, A.; Ward, P. A.; Ruf, W.; Schäfer, K.; Bosmann, M.
2023 Proceedings of the National Academy of Sciences
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Visualization of Metabolites and Microbes at High Spatial Resolution Using MALDI Mass Spectrometry Imaging and in Situ Fluorescence Labeling.Bourceau, P.; Geier, B.; Suerdieck, V.; Bien, T.; Soltwisch, J.; Dreisewerd, K.; Liebeke, M.
2023 Nat Protoc
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S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritisvon Wulffen, M.; Luehrmann, V.; Robeck, S.; Russo, A.; Fischer-Riepe, L.; van den Bosch, M.; van Lent, P.; Loser, K.; Gabrilovich, D. I.; Hermann, S.; Roth, J.; Vogl, T.
2023 Cell Reports
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DRANquilizing neutrophil function in chronic liver diseaseGroba, S. R., & Soehnlein, O.
2023 Journal of Hepatology.
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Non-functional TGF-β/ALK1/ENG Signaling Pathway supports neutrophil pro-angiogenic activity in Hereditary Hemorrhagic TelangiectasiaDuerig, I., Pylaeva, E., Ozel, I., Weinwright, S., Thiel, I., Bordbari, S., Domnich, M., Siakaeva, E., Lakomek, A., Toppe, F., Schleupner, C., Geisthoff, U., Lang, S., Droege, F., & Jablonska, J.
2023 Journal of leukocyte biology
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Visualization of Differential Cardiolipin Profiles in Murine Retinal Cell Layers by High-Resolution MALDI Mass Spectrometry ImagingBessler, S.; Soltwisch, J.; Dreisewerd, K.
2023 Anal. Chem.
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Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanomaMartins Nascentes Melo, L.; Herrera-Rios, D.; Hinze, D.; Löffek, S.; Oezel, I.; Turiello, R.; Klein, J.; Leonardelli, S.; Westedt, I.-V.; Al-Matary, Y.; Egea-Rodriguez, S.; Brenzel, A.; Bau, M.; Sucker, A.; Hadaschik, E.; Wirsdörfer, F.; Hanenberg, H.; Uhlenbrock, N.; Rauh, D.; Poźniak, J.; Rambow, F.; Marine, J.-C.; Effern, M.; Glodde, N.; Schadendorf, D.; Jablonska, J.; Hölzel, M.; Helfrich, I.
2023 J Immunother Cancer
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Finerenone Added to RAS/SGLT2 Blockade for Chronic Kidney Disease in Alport Syndrome. Results of a Randomized Controlled Trial with Col4a3-/- Mice.Zhu, Z.; Rosenkranz, K. A.; Kusunoki, Y.; Li, C.; Klaus, M.; Gross, O.; Angelotti, M.-L.; Antonelli, G.; Cirillo, L.; Romagnani, P.; Bouteldja, N.; Sadr, A. V.; Bülow, R. D.; Boor, P.; Anders, H.-J.
2023 J Am Soc Nephrol
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Asymptomatic Hyperuricaemia in Chronic Kidney Disease: Mechanisms and Clinical Implications. |
The Five Types of Glomerulonephritis Classified by Pathogenesis, Activity, and Chronicity (GN-AC)Romagnani, P.; Kitching, A. R.; Leung, N.; Anders, H.-J.
2023 Nephrol Dial Transplant
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Inflammaging aggravates stroke pathology |
The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammationGatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.
2023 Immunity
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The Roles of Toll-like Receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for Monocyte Activation by the DAMP S100A8/S100A9Möller, A.; Jauch-Speer, S.-L.; Gandhi, S.; Vogl, T.; Roth, J.; Fehler, O.
2023 Front Immunol
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S100A8/S100A9 Integrates F-Actin and Microtubule Dynamics to Prevent Uncontrolled Extravasation of LeukocytesWolf, M.; Joseph, R.; Austermann, J.; Scharrnbeck-Davis, C.; Hermann, S.; Roth, J.; Vogl, T.
2023 Biomedicines
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Macrophage Function in Adipose Tissue Homeostasis and Metabolic InflammationChavakis, T.; Alexaki, V. I.; Ferrante, A. W.
2023 Nat Immunol
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Rapid and Fully Automated Blood Vasculature Analysis in 3D Light-Sheet Image Volumes of Different OrgansSpangenberg, P.; Hagemann, N.; Squire, A.; Förster, N.; Krauß, S. D.; Qi, Y.; Yusuf, A. M.; Wang, J.; Grüneboom, A.; Kowitz, L.; Korste, S.; Totzeck, M.; Cibir, Z.; Tuz, A. A.; Singh, V.; Siemes, D.; Struensee, L.; Engel, D. R.; Ludewig, P.; Nascentes Melo, L. M.; Helfrich, I.; Chen, J.; Gunzer, M.; Hermann, D. M.; Mosig, A.
2023 Cell Reports Methods
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The Angiopoietin Receptor Tie2 Is Atheroprotective in Arterial EndotheliumAnisimov, A.; Fang, S.; Hemanthakumar, K. A.; Örd, T.; van Avondt, K.; Chevre, R.; Toropainen, A.; Singha, P.; Gilani, H.; Nguyen, S. D.; Karaman, S.; Korhonen, E. A.; Adams, R. H.; Augustin, H. G.; Öörni, K.; Soehnlein, O.; Kaikkonen, M. U.; Alitalo, K. 2023, 1–15.
2023 Nat Cardiovasc Res
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A20 and the Noncanonical NF-κB Pathway Are Key Regulators of Neutrophil Recruitment during Fetal OntogenyRohwedder, I.; Wackerbarth, L. M.; Heinig, K.; Ballweg, A.; Altstätter, J.; Ripphahn, M.; Nussbaum, C.; Salvermoser, M.; Bierschenk, S.; Straub, T.; Gunzer, M.; Schmidt-Supprian, M.; Kolben, T.; Schulz, C.; Ma, A.; Walzog, B.; Heinig, M.; Sperandio, M.
2023 JCI Insight
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Analyzing Mitochondrial Respiration of Human Induced Pluripotent Stem Cell-Derived Myeloid Progenitors Using Seahorse TechnologyFan, Y.; Mizoguchi, Y.; Tatematsu, M.; Linder, M. I.; Frenz, S.; Choi, J.; Klein, C.
2023 STAR Protoc
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Complex Regulation of Alarmins S100A8/A9 and Secretion via Gasdermin-D Pores Exacerbates Autoinflammation in Familial Mediterranean FeverJorch, S. K.; McNally, A.; Berger, P.; Wolf, J.; Kaiser, K.; Chetrusca Covash, A.; Robeck, S.; Pastau, I.; Fehler, O.; Jauch-Speer, S.-L.; Hermann, S.; Schäfers, M.; Van Gorp, H.; Kanneganti, A.; Dehoorne, J.; Haerynck, F.; Penco, F.; Gattorno, M.; Chae, J. J.; Kubes, P.; Lamkanfi, M.; Wullaert, A.; Sperandio, M.; Vogl, T.; Roth, J.; Austermann, J.
2023 J Allergy Clin Immunol
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Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic MicePan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O.
2023 Circulation
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Targeting Neutrophil Extracellular Traps (NETs) Ameliorates Inflammation in Murine Psoriasiform DermatitisHollstein, M. M.; Manzke, V.; Scheidmann, S. E. F.; Schrenker, S.; Schaffrinski, M.; Neubert, E.; Kramer, D.; Raker, V. K.; Schön, M. P.; Erpenbeck, L.
2023 Journal of Dermatological Science
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Glycolytic Side Pathways Regulating Macrophage Inflammatory Phenotypes and FunctionsDionísio, F.; Tomas, L.; Schulz, C.
2023 Am J Physiol Cell Physiol
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Non-Invasive Mapping of Systemic Neutrophil Dynamics upon Cardiovascular InjuryBouvain, P.; Ding, Z.; Kadir, S.; Kleimann, P.; Kluge, N.; Tiren, Z.-B.; Steckel, B.; Flocke, V.; Zalfen, R.; Petzsch, P.; Wachtmeister, T.; John, G.; Subramaniam, N.; Krämer, W.; Strasdeit, T.; Mehrabipour, M.; Moll, J. M.; Schubert, R.; Ahmadian, M. R.; Bönner, F.; Boeken, U.; Westenfeld, R.; Engel, D. R.; Kelm, M.; Schrader, J.; Köhrer, K.; Grandoch, M.; Temme, S.; Flögel, U.
2023 Nature Cardiovascular Research
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Hijacking CD177 for whole-body visualization of neutrophil dynamicsSoehnlein, O.
2023 Nature Cardiovascular Research
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Longitudinal in vivo monitoring of atheroprogression in hypercholesterolemic mice using photoacoustic imagingFerraro, B.; Giustetto, P.; Schengel, O.; Weckbach, L.; Maegdefessel, L.; Soehnlein, O.
2023 Thromb Haemost
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Human Genetic Defects in SRP19 and SRPRA Cause Severe Congenital Neutropenia with Distinctive Proteome ChangesLinder, M. I.; Mizoguchi, Y.; Hesse, S.; Csaba, G.; Tatematsu, M.; Łyszkiewicz, M.; Zietara, N.; Jeske, T.; Hastreiter, M.; Rohlfs, M.; Liu, Y.; Grabowski, P.; Ahomaa, K.; Maier-Begandt, D.; Schwestka, M.; Pazhakh, V.; Isiaku, A.; Briones Miranda, B.; Blombery, P.; Saito, M. K.; Rusha, E.; Alizadeh, Z.; Pourpak, Z.; Kobayashi, M.; Rezaei, N.; Unal, E.; Hauck, F.; Drukker, M.; Walzog, B.; Rappsilber, J.; Zimmer, R.; Lieschke, G. J.; Klein, C.
2023 Blood
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During Early Stages of Cancer, Neutrophils Initiate Anti-Tumor Immune Responses in Tumor-Draining Lymph NodesPylaeva, E.; Korschunow, G.; Spyra, I.; Bordbari, S.; Siakaeva, E.; Ozel, I.; Domnich, M.; Squire, A.; Hasenberg, A.; Thangavelu, K.; Hussain, T.; Goetz, M.; Lang, K. S.; Gunzer, M.; Hansen, W.; Buer, J.; Bankfalvi, A.; Lang, S.; Jablonska, J.
2022 Cell Reports
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Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammationMauersberger, C.; Sager, H. B.; Wobst, J.; Dang, T. A.; Lambrecht, L.; Koplev, S.; Stroth, M.; Bettaga, N.; Schlossmann, J.; Wunder, F.; Friebe, A.; Björkegren, J. L. M.; Dietz, L.; Maas, S. L.; van der Vorst, E. P. C.; Sandner, P.; Soehnlein, O.; Schunkert, H.; Kessler, T.
2022 Nature Cardiovascular Research
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N1 versus N2 and PMN-MDSC: A critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncologyAntuamwine, B. B.; Bosnjakovic, R.; Hofmann-Vega, F.; Wang, X.; Theodosiou, T.; Iliopoulos, I.; Brandau, S.
2022 Immunological Reviews
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Expansion microscopy of neutrophil nuclear structure and extracellular trapsHolsapple, J. S.; Schnitzler, L.; Rusch, L.; Baldeweg, T. H.; Neubert, E.; Kruss, S.; Erpenbeck, L.
2022 Biophysical Reports
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Role of S100A8/A9 in Platelet–Neutrophil Complex Formation during Acute InflammationRevenstorff, J.; Ludwig, N.; Hilger, A.; Mersmann, S.; Lehmann, M.; Grenzheuser, J. C.; Kardell, M.; Bone, J.; Kötting, N. M.; Marx, N. C.; Roth, J.; Vogl, T.; Rossaint, J.
2022 Cells
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Pathological neutrophil migration predicts adverse outcomes in hospitalized patients with liver cirrhosisLanger, M.-M.; Sichelschmidt, S.; Bauschen, A.; Bornemann, L.; Guckenbiehl, S.; Gunzer, M.; Lange, C. M.
2022 Liver International
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Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recoveryTuz, A. A.; Hasenberg, A.; Hermann, D. M.; Gunzer, M.; Singh, V.
2022 Frontiers in Immunology
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Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on MonocytesRusso, A.; Schürmann, H.; Brandt, M.; Scholz, K.; Matos, A. L. L.; Grill, D.; Revenstorff, J.; Rembrink, M.; von Wulffen, M.; Fischer-Riepe, L.; Hanley, P. J.; Häcker, H.; Prünster, M.; Sánchez-Madrid, F.; Hermann, S.; Klotz, L.; Gerke, V.; Betz, T.; Vogl, T.; Roth, J.
2022 Advanced Science
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Neutrophils in aging and aging-related pathologiesVan Avondt, K.; Strecker, J.-K.; Tulotta, C.; Minnerup, J.; Schulz, C.; Soehnlein, O.
2022 Immunological Reviews
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Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular diseasePetzold, T.; Zhang, Z.; Ballesteros, I.; Saleh, I.; Polzin, A.; Thienel, M.; Liu, L.; Ul Ain, Q.; Ehreiser, V.; Weber, C.; Kilani, B.; Mertsch, P.; Götschke, J.; Cremer, S.; Fu, W.; Lorenz, M.; Ishikawa-Ankerhold, H.; Raatz, E.; El-Nemr, S.; Görlach, A.; Marhuenda, E.; Stark, K.; Pircher, J.; Stegner, D.; Gieger, C.; Schmidt-Supprian, M.; Gaertner, F.; Almendros, I.; Kelm, M.; Schulz, C.; Hidalgo, A.; Massberg, S.
2022 Immunity
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The Role of Neutrophils in Trained ImmunityKalafati, L.; Hatzioannou, A.; Hajishengallis, G.; Chavakis, T.
2022 Immunological Reviews
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Glutamine Prevents Acute Kidney Injury by Modulating Oxidative Stress and Apoptosis in Tubular Epithelial CellsThomas, K.; Zondler, L.; Ludwig, N.; Kardell, M.; Lüneburg, C.; Henke, K.; Mersmann, S.; Margraf, A.; Spieker, T.; Tekath, T.; Velic, A.; Holtmeier, R.; Hermann, J.; Jankowski, V.; Meersch, M.; Vestweber, D.; Westphal, M.; Roth, J.; Schäfers, M. A.; Kellum, J. A.; Lowell, C. A.; Rossaint, J.; Zarbock, A.
2022 JCI Insight
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PMN-MDSC in newborns: Regulation of the regulatorsJablonska, J.; Brandau, S.
2022 Journal of Leukocyte Biology
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Neutrophil circadian rhythm is associated with different outcomes of acute kidney injury due to cholesterol crystal embolismShi, C.; Zhao, D.; Lyubenov, L.; Motrapu, M.; Li, N.; Steiger, S.; Mammadova-Bach, E.; Yang, L.; Liu, D.; Anders, H.-J.
2022 Frontiers in Cardiovascular Medicine
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AIMing 2 treat atherosclerosisSoehnlein, O.; Tall, A. R.
2022 Nature Reviews Cardiology
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Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formationSohrabi, Y.; Reinecke, H.; Soehnlein, O.
2022 Signal Transduction and Targeted Therapy
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Mechanisms and Therapeutic Modulation of Neutrophil-Mediated InflammationHajishengallis, G.; Chavakis, T.
2022 Journal of Dental Research
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Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human NeutrophilsSchirrmann, R.; Erkelenz, M.; Lamers, K.; Sritharan, O.; Nachev, M.; Sures, B.; Schlücker, S.; Brandau, S.
2022 American Chemical Society
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