Intracellular processing of receptor signalling towards functional output in terms of gene expression or behaviour is key to the plasticity of immune cells. Project area B unites projects that aim at understanding how intracellular processing of signals regulates neutrophil function. Specifically, the projects cover the rearrangement of the actin cytoskeleton, the importance of nuclear receptors and transcription factors for gene expression, as well as the ability of neutrophils and their progenitors to be trained.