TRR332

The Collaborative Research Centre TRR332 is a DFG-funded consortium dedicated to develop an improved understanding of neutrophil biology. Our studies will reveal mechanisms of how the tissue environment regulates neutrophil production and phenotypes, how neutrophil activity is controlled intracellularly and how neutrophils function in different disease contexts. In the second funding period we will advance our foundational work towards disease models with relevance for human pathology. Specifically, we will focus on three disease entities with great socioeconomic burden and relevance to neutrophil biology, namely vascular inflammation, cancer, and infection. Such approach will not only reveal important aspects of the fine-tuned regulatory mechanisms of neutrophil activation but also permit the generation of tailored intervention strategies.