Dissecting the anti-tumour effects of trained neutrophils

Neutrophils exert both pro- and anti-tumour activities. A frequent scenario in cancer is that tumours hijack granulopoiesis resulting in a tumour-promoting neutrophil phenotype. Trained innate immunity indicates that some stimuli can induce, via epigenetic rewiring, long-term functional changes in myeloid cells and their progenitors, leading to an increased reaction upon exposure to a secondary challenge. Here we will dissect how innate immune training of granulopoiesis and neutrophils promotes anti-tumour activity. Our work will establish innate immune training of neutrophils as a novel adjuvant tumour immunotherapy.

Chavakis
Triantafyllos, MD

TUD

Institute for Clinical Chemistry and Laboratory Medicine

Team

Kalafati
Lydia, PhD student

TUD

Sidiropoulos
Panagiotis, PhD student

TUD

Publications

A2 B4 Z1 Formyl Peptide Receptor 2 (FPR2) Regulates Dendritic Cell Metabolism and Th17 Cell Differentiation during Neuroinflammation Lim, J.-H.; Neuwirth, A.; Chung, K.-J.; Grossklaus, S.; Soehnlein, O.; Hajishengallis, G.; Chavakis, T. 2024 Front. Immunol
B4 Central Trained Immunity and Its Impact on Chronic Inflammatory and Autoimmune Diseases Hajishengallis, G.; Chavakis, T. 2024 Journal of Allergy and Clinical Immunology https://doi.org/10.1016/j.jaci.2024.06.005
B4 Clonal Hematopoiesis Driven by Mutated DNMT3A Promotes Inflammatory Bone Loss Wang, H.; Divaris, K.; Pan, B.; Li, X.; Lim, J.-H.; Saha, G.; Barovic, M.; Giannakou, D.; Korostoff, J. M.; Bing, Y.; Sen, S.; Moss, K.; Wu, D.; Beck, J. D.; Ballantyne, C. M.; Natarajan, P.; North, K. E.; Netea, M. G.; Chavakis, T.; Hajishengallis, G. * equal contribution 2024 Cell https://doi.org/10.1016/j.cell.2024.05.003
A1 B4 Novel Possibilities for Targeting Neutrophils in Cancer Silvestre-Roig, C.; Kalafati, L.; Chavakis, T. 2024 Sig Transduct Target Ther https://doi.org/10.1038/s41392-024-01786-4
B4 Potent induction of trained immunity by Saccharomyces cerevisiae β-glucans Vuscan, P.; Kischkel, B.; Hatzioannou, A.; Markaki, E.; Sarlea, A.; Tintoré, M.; Cuñé, J.; Verginis, P.; de Lecea, C.; Chavakis, T.; Joosten, L. A. B.; Netea, M. G. 2024 Frontiers in Immunology https://doi.org/10.3389/fimmu.2024.1323333
B4 CD38 promotes hematopoietic stem cell dormancy Ibneeva, L.; Singh, S. P.; Sinha, A.; Eski, S. E.; Wehner, R.; Rupp, L.; Kovtun, I.; Pérez-Valencia, J. A.; Gerbaulet, A.; Reinhardt, S.; Wobus, M.; von Bonin, M.; Sancho, J.; Lund, F.; Dahl, A.; Schmitz, M.; Bornhäuser, M.; Chavakis, T.; Wielockx, B.; Grinenko, T. 2024 PLoS Biol https://doi.org/10.1371/journal.pbio.3002517
B4 An IL-10/DEL-1 Axis Supports Granulopoiesis and Survival from Sepsis in Early Life Vergadi, E.; Kolliniati, O.; Lapi, I.; Ieronymaki, E.; Lyroni, K.; Alexaki, V. I.; Diamantaki, E.; Vaporidi, K.; Hatzidaki, E.; Papadaki, H. A.; Galanakis, E.; Hajishengallis, G.; Chavakis, T.; Tsatsanis, C. 2024 Nat Commun https://doi.org/10.1038/s41467-023-44178-y
B4 A Novel Macrolide-Del-1 Axis to Regenerate Bone in Old Age Sirisereephap, K.; Tamura, H.; Lim, J.-H.; Surboyo, M. D. C.; Isono, T.; Hiyoshi, T.; Rosenkranz, A. L.; Sato-Yamada, Y.; Domon, H.; Ikeda, A.; Hirose, T.; Sunazuka, T.; Yoshiba, N.; Okada, H.; Terao, Y.; Maeda, T.; Tabeta, K.; Chavakis, T.; Hajishengallis, G.; Maekawa, T. 2024 iScience https://doi.org/10.1016/j.isci.2024.108798.
B4 Macrophage Function in Adipose Tissue Homeostasis and Metabolic Inflammation Chavakis, T.; Alexaki, V. I.; Ferrante, A. W. 2023 Nat Immunol https://doi.org/10.1038/s41590-023-01479-0
B4 The Role of Neutrophils in Trained Immunity Kalafati, L.; Hatzioannou, A.; Hajishengallis, G.; Chavakis, T. 2022 Immunological Reviews https://doi.org/10.1111/imr.13142
B4 Mechanisms and Therapeutic Modulation of Neutrophil-Mediated Inflammation Hajishengallis, G.; Chavakis, T. 2022 Journal of Dental Research https://doi.org/10.1177/00220345221107602