Core Projects

Visualizing neutrophils in context

Neutrophils are key mediators of the immune response, engaging in both local and systemic communication. They interact with neighbouring cells and distant immune compartments, influencing their lifespan, functional state, and activation. This crosstalk involves diverse molecular classes, including lipids, metabolites, nucleic acids, and peptides and their respective receptors. In the first funding period, we have established a platform that facilitates the analysis of neutrophils in their habitat using state of the art Matrix-assisted Laser Desorption Ionisation Mass Spectrometry Imaging (MALDI-MSI) for the analysis of lipids and multiplex microscopyIn the second funding period, we
will advance in situ molecular profiling of neutrophils and their microenvironment using MALDI-MSI to include metabolites and signalling molecules. Multiplex microscopy is extended to multiplex RNA analysis via FISH. Both spatial methods are complemented by Deep Visual Proteomics (DVP), using laser microdissection combined with low-input liquid chromatography–mass spectrometry (LC-MS) of tissue-derived neutrophils and areas. Finally, we implement single-cell lipidomic and proteomic analyses of both circulating and tissue-resident neutrophils. Thus, this central project provides state-of-the-art imaging modalities and serves as a platform to visualize and analyse context-dependent neutrophil biology.

Publications

A2 Z1 Genetic Tool for Specific Tracking of Mature Neutrophils Cao, J.; Yaw, H. P.; Yi, S.; Zhou, Y.; Qin, S.; Wang, Y.; da Costa, R.; Zhang, L.; Wu, D.; Chen, C.; Ng, M.; Kwok, I.; Soehnlein, O.; Chen, X.; Wan, J.; Ng, L. G. 2026 hLife https://doi.org/10.1016/j.hlife.2026.05.007
A1 A2 A3 A5 B3 B4 C5 Z1 Divergent Granulopoiesis at Extramedullary Sites Safeguards Antibacterial Host Defense Silvestre-Roig, C.; Chevre, R.; Farjia, M.; Bender, A.; Vöcking, L. M.; Richter, M.; Hageb, A.; Suerdieck, V.; Arenas Cerro, F. J.; Braster, Q.; Guzman, M.; Sintes, J.; Sharma, S.; Lemnitzer, P.; Tulotta, C.; Börgeling, Y.; Herrero-Cervera, A.; Flueter, H.; Reinartz Groba, S. N.; Ahern, D.; Osei-Sarpong, C.; Zimmer, R.; Alonso-Gonzalez, N.; Ortega, E.; Lienenklaus, S.; Kalinke, U.; Ludwig, S.; Engel, D. R.; Rosenbauer, F.; Monaco, C.; Dersch, P.; Kibler, A.; Cerutti, A.; Chavakis, T.; Benedito, R.; Hidalgo, A.; Jablonska, J.; Palomino-Segura, M.; Soehnlein, O. 2026 Sci Immunol https://doi.org/10.1126/sciimmunol.adw7077
A2 Z1 Integrated Single-Cell Mass Spectrometry Imaging and Immunofluorescence Microscopy for Multimodal Characterization of Human Immune Cells Bessler, S.; Richter, M.; Schwenzfeier, J.; Reinartz Groba, S. N.; Trebicka, J.; Dreisewerd, K.; Soltwisch, J.; Soehnlein, O. 2026 Anal Chem https://doi.org/10.1021/acs.analchem.6c00381
A2 A4 C3 Z1 IL-1α Drives a Tumor-Stroma-Neutrophil Axis through Inflammatory Fibroblast Activation in Head and Neck Cancer Hanschmann, E.-M.; Bruderek, K.; Hofmann-Vega, F.; Schmidt, M.; Budeus, B.; Oberlies, W.; Wei, X.; Richter, M.; Lemm, S.; Szlachetko, J. A.; Ryan, S.; Bader, A.; Daser, A.; Lang, S.; Maier-Begandt, D.; Hussain, T.; Soehnlein, O.; Brandau, S. 2026 bioRxiv https://doi.org/10.64898/2026.01.20.700440
A2 B1 C3 Z1 Mutations in VPS18 Lead to a Neutrophil Maturation Defect Associated with Disturbed Vesicle Homeostasis Gao, J.; Bader, A.; Linder, M. I.; Cheng, J.; Richter, M.; Da Costa, R.; Zehrer, A.; Mitt, K.; Popper, B.; Meissner, F.; Wei, X.; De Vega Gómez, E.; Tatematsu, M.; Rohlfs, M.; Frenz-Wiessner, S.; Kiziltug, M.; Somekh, I.; Yacobovich, J.; Steinberg-Shemer, O.; Somech, R.; Soehnlein, O.; Schmid, B.; Klein, C.; Walzog, B.; Maier-Begandt, D. 2026 Cell Death Dis https://doi.org/10.1038/s41419-025-08338-w
A3 Z1 Interleukin-1α Alters Megakaryocyte Maturation, Promotes Emperipolesis, and Induces a Distinct Proteomic Profile Kolman, R.; Voß, H.; Bertović, I.; Peradinović, J.; Munitić, I.; Engel, D. R.; Shevchuk, O.; Jurak Begonja, A. 2026 J. Thromb. Haemost https://doi.org/10.1016/j.jtha.2025.08.037
A3 C6 Z1 Astrocytic PIEZO Activation by Heartbeat Sound Promotes Extracellular Matrix and Maturation in Human Brain Organoids Ferreira Oliveira, A.; Rambow, F.; Makhzami, S.; Nikolaev, Y. A.; Novak, A.; Shevchuk, O.; Voss, H.; Engel, D. R.; Schult, P. A.; Pillath-Eilers, M.; Kaltwasser, B.; Brockmeier, U.; Kleinschnitz, C.; Hermann, D. M.; Dzyubenko, E. 2025 bioRxiv https://doi.org/10.1101/2025.10.21.683816
A1 A2 B2 B3 C1 C3 C6 C7 E Z1 The Nuclear Receptor NR4A1 Serves as a Neutrophil-Intrinsic Regulator Mitigating Stroke Severity Strecker, J.-K.; Schmidt, Y.; Liebmann, M.; Walter, C.; Roth, S.; Aleth, H.; Börsch, A.-L.; Schmidt-Pogoda, A.; Beuker, C.; Yusuf, A. M.; Revenstorff, J.; Osei-Sarpong, C.; Krafft, L.; Schwarze, A.-S.; Heming, M.; Richter, M.; Kuhlmann, T.; Hucke, S.; Heming, J.-N.; Hansen, U.; Hagemann, N.; Bader, A.; Gao, J.; Walzog, B.; Maier-Begandt, D.; Chevre, R.; Hanschmann, E.-M.; Lücke, M.; Sommer, C.; Hermann, D. M.; Roth, J.; Thomas, C.; Meyer Zu Hörste, G.; Gunzer, M.; Vogl, T.; Zarbock, A.; Rosenbauer, F.; Silvestre-Roig, C.; Söhnlein, O.; Klotz, L.; Minnerup, J. 2025 bioRxiv https://doi.org/10.1101/2025.09.19.677282
A2 A3 B4 B6 C5 C6 Z1 TSP1/TGF-Β1 Drives Arachidonic Acid Metabolism to Orchestrate Neutrophil Swarming Widera, L.; Spangenberg, P.; Siemes, D.; Bessler, S.; Bottek, J.; Voss, H.; Novak, A.; Hueser, D.; Richter, M.; Potthoff, A.; Siebels, B.; Moritz, M.; Gocke, A.; Thiebes, S.; Tautges, S.; Chavakis, T.; Jablonska, J.; Lämmermann, T.; Gunzer, M.; Schlüter, H.; Hahn, J.; Grüneboom, A.; Soehnlein, O.; Dreisewerd, K.; Soltwisch, J.; Shevchuk, O.; Engel, D. R. 2025 bioRxiv https://doi.org/10.1101/2025.11.25.688397
A3 A5 C2 Z1 G-CSF/NAMPT Signaling Drives Neutrophil Dysfunction and Enhances Bacterial Infection Susceptibility in Cancer Patients Pylaeva, E.; Tollrian, L.; Riedesel, J.; Shevchuk, O.; Thiel, I.; Ozel, I.; Kabankova, N.; Voß, H.; Siebels, B.; Schlüter, H.; Haist, C.; Hanenberg, H.; Mattheis, S.; Kürten, C.; Sperandio, M.; Kehrmann, J.; Engel, D. R.; Lang, S.; Jablonska, J. 2025 Nat Commun https://doi.org/10.1038/s41467-025-67471-4
A2 Z1 Architecture of the Neutrophil Compartment Cerezo-Wallis, D.; Rubio-Ponce, A.; Richter, M.; Pitino, E.; Kwok, I.; Marteletto, G.; Guanolema-Coba, A. C.; Shih, C.; Huang, R.-K.; Moraga, A.; Bravo, N. B.; Doré, S.; Callejas, S.; Aragonés, D. G.; Jiménez-Carretero, D.; Martin, D.; Ovadia, S.; Vicanolo, T.; Crainiciuc, G.; Sicilia, J.; Deng, T.; Martin, A.; Zhang, J.; Cuartero, M. I.; Giraldo, D. M.; Garcia-Culebras, A.; Aroca-Crevillen, A.; Martín-Salamanca, S.; Torroja, C.; Ruiz, M.; Ruano, I.; Ng, M. S. F.; Hou, J.; Wang, Y.; Zhang, M.; Pu, J.; Herruzo, A.; Van Oordt, D. C.; Chang, S.; Downie, A. E.; Chen, F.; Graham, A. L.; Gause, W. C.; Fiset, P. O.; Spicer, J. D.; Heyn, H.; Zuriaga, M. A.; Bernal, J. A.; Udalova, I. A.; Moro, M. A.; De Bock, K.; Dopazo, A.; Fuster, J. J.; Sánchez-Cabo, F.; Nieto, J. C.; Calvo, G. F.; Skokowa, J.; Soehnlein, O.; Quail, D. F.; Walsh, L. A.; Ng, L. G.; Hidalgo, A.; Ballesteros, I. 2025 Nature https://doi.org/10.1038/s41586-025-09807-0
A2 Z1 Maladaptive Emergency Granulopoiesis Predicts Poor Outcomes in Patients Hospitalized with Decompensated Cirrhosis Aguilar, F.; Lozano, J. J.; Clària, J.; Groba, S. N. R.; Richter, M.; Jiménez-Gracia, L.; Grange, P. de la; Jolly, A.; Praktiknjo, M.; Sánchez-Garrido, C.; Raposo, E. M. U.; García-Torre, B.; Laleman, W.; Gómez-Cabrero, D.; Palomino-Echeverria, S.; Iglesias, E. H.; Farias, A. Q.; Marciano, S.; Caraceni, P.; Trebicka, J.; Cerutti, A.; Arroyo, V.; Heyn, H.; Nieto, J. C.; Soehnlein, O.; Rautou, P.-E.; Moreau, R.; on behalf of the DECISION Consortium. 2025 J Hepatol https://doi.org/10.1016/j.jhep.2025.11.012
A3 C3 Z1 SCAMP3 Is Essential for Proper Formation and Function of Neutrophil Granules Bader, A.; Gao, J.; Reiter, N.; Siemes, D.; Zehrer, A.; Wei, X.; Hepper, I.; de Vega Gómez, E.; Schmid, B.; Forné, I.; Engel, D. R.; Walzog, B.; Maier-Begandt, D. 2025 J Leukoc Biol https://doi.org/10.1093/jleuko/qiaf153
A2 A5 C6 Z1 Hypoxic-Ischemic Brain Injury in Neonatal Mice Sequentially Recruits Neutrophils with Dichotomous Phenotype and Function Richter, M.; Diesterbeck, E.; Pylaeva, E.; Labusek, N.; Köster, C.; Nagel, D.; Karsch, L.; Fischer, A. J.; Sous, M.; Jung, M.; Chevre, R.; Hagemann, N.; Andersson, E. A.; Ek, C. J.; Singh, V.; Hermann, D. M.; Gunzer, M.; Jablonska, J.; Felderhoff-Müser, U.; Bendix, I.; Soehnlein, O.; Herz, J. 2025 Nat Commun https://doi.org/10.1038/s41467-025-65517-1
A2 Z1 Spatial Biology Using Single-Cell Mass Spectrometry Imaging and Integrated Microscopy Potthoff, A.; Schwenzfeier, J.; Niehaus, M.; Bessler, S.; Hoffmann, E.; Soehnlein, O.; Höhndorf, J.; Dreisewerd, K.; Soltwisch, J. 2025 Nat Commun https://doi.org/10.1038/s41467-025-64603-8.
A2 Z1 Effect of Long-Term Mediterranean versus Low-Fat Diet on Neutrophil Count, and Type 2 Diabetes Mellitus Remission in Patients with Coronary Heart Disease: Results from the CORDIOPREV Study Boughanem, H.; Gutierrez-Mariscal, F. M.; Arenas-de Larriva, A. P.; Torres-Peña, J. D.; Romero-Cabrera, J. L.; Rangel-Zuñiga, O. A.; García-Fernández, H.; Podadera-Herreros, A.; Rodríguez-Cantalejo, F.; Soehnlein, O.; Macias-Gonzalez, M.; Tinahones, F. J.; Yubero Serrano, E. M.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J. 2025 Nutr Diabetes https://doi.org/10.1038/s41387-025-00360-3
A2 Z1 SiglecF+ Neutrophils Link Periodontitis to Impaired Post-Myocardial Infarction Repair Boughanem, H.; Herrero-Cervera, A.; Soehnlein, O. 2025 Eur Heart J https://doi.org/10.1093/eurheartj/ehaf165
A3 Z1 A Reference Database Enabling In-Depth Proteome and PTM Analysis of Mouse Immune Cells Siemes, D.; Voss, H.; Benvenuti, F.; Simoncello, F.; Kopczynski, D.; Siebels, B.; Schlüter, H.; Kollipara, L.; Sickmann, A.; Engel, D. R.; Shevchuk, O. 2025 Sci Data https://doi.org/10.1038/s41597-025-04829-9
A3 C6 Z1 Inhibition of Tumour Necrosis Factor Alpha by Etanercept Attenuates Shiga Toxin-Induced Brain Pathology Christ, R.; Siemes, D.; Zhao, S.; Widera, L.; Spangenberg, P.; Lill, J.; Thiebes, S.; Bottek, J.; Borgards, L.; Pinho, A. G.; Silva, N. A.; Monteiro, S.; Jorch, S. K.; Gunzer, M.; Siebels, B.; Voss, H.; Schlüter, H.; Shevchuk, O.; Chen, J.; Engel, D. R. 2025 J Neuroinflammation https://doi.org/10.1186/s12974-025-03356-z
A2 C5 Z1 Multiomic Analysis Uncovers a Continuous Spectrum of Differentiation and Wnt-MDK-Driven Immune Evasion in Hepatoblastoma Münter, D.; de Faria, F. W.; Richter, M.; Aranda-Pardos, I.; Hotfilder, M.; Walter, C.; Paga, E.; Inserte, C.; Albert, T. K.; Roy, R.; Rahman, S.; Riedel, N. C.; Müller, V.; Pascher, A.; Wiebe, K.; Schmid, I.; Vokuhl, C.; Winkler, B.; Jüttner, E.; Vieth, S.; Mücke, U.; Kluiver, T. A.; Peng, W. C.; Rossig, C.; Schlué, J.; Madadi-Sanjani, O.; Sandmann, S.; Hartmann, W.; A-Gonzalez, N.; Soehnlein, O.; Kerl, K. 2025 J Hepatol https://doi.org/10.1016/j.jhep.2025.01.031
A2 A3 C6 Z1 msiFlow: automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysis Spangenberg, P.; Bessler, S.; Widera, L.; Bottek, J.; Richter, M.; Thiebes, S.; Siemes, D.; Krauß, S. D.; Migas, L. G.; Kasarla, S. S.; Phapale, P.; Kleesiek, J.; Führer, D.; Moeller, L. C.; Heuer, H.; Van de Plas, R.; Gunzer, M.; Soehnlein, O.; Soltwisch, J.; Shevchuk, O.; Dreisewerd, K.; Engel, D. R. 2025 Nat Commun https://doi.org/10.1038/s41467-024-55306-7
A2 Z1 Altered shear stress of blood flow causes plasma membrane damage in endothelial cells Raj, N.; Pan, C.; Starke, A. M.; L. Matos, A. L.; Soehnlein, O.; Gerke, V. 2025 Blood Vessels Thromb Hemost https://doi.org/10.1016/j.bvth.2024.100040
A2 Z1 β-Glucan Reprograms Neutrophils to Promote Disease Tolerance against Influenza A Virus Khan, N.; Tran, K. A.; Chevre, R.; Locher, V.; Richter, M.; Sun, S.; Sadeghi, M.; Pernet, E.; Herrero-Cervera, A.; Grant, A.; Saif, A.; Downey, J.; Kaufmann, E.; Khader, S. A.; Joubert, P.; Barreiro, L. B.; Yipp, B. G.; Soehnlein, O.; Divangahi, M. 2025 Nat Immunol https://doi.org/10.1038/s41590-024-02041-2
A2 Z1 Mediterranean Diet, Neutrophil Count, and Carotid Intima-Media Thickness in Secondary Prevention: The CORDIOPREV Study Boughanem, H.; Torres-Peña, J. D.; Arenas-de Larriva, A. P.; Romero-Cabrera, J. L.; Gómez-Luna, P.; Martín-Piedra, L.; Rodríguez-Cantalejo, F.; Tinahones, F. J.; Yubero Serrano, E. M.; Soehnlein, O.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J. 2024 Eur Heart J https://doi.org/10.1093/eurheartj/ehae836.
A2 B4 Z1 Formyl Peptide Receptor 2 (FPR2) Regulates Dendritic Cell Metabolism and Th17 Cell Differentiation during Neuroinflammation Lim, J.-H.; Neuwirth, A.; Chung, K.-J.; Grossklaus, S.; Soehnlein, O.; Hajishengallis, G.; Chavakis, T. 2024 Front Immunol
A2 Z1 Neuro-Immune Crosstalk in Hematopoiesis, Inflammation, and Repair Akinyemi, D. E.; Chevre, R.; Soehnlein, O. 2024 Trends in Immunology https://doi.org/10.1016/j.it.2024.06.005
A2 Z1 Targeting Extranuclear Histones to Alleviate Acute and Chronic Inflammation Nicolaes, G. A. F.; Soehnlein, O. 2024 Trends Pharmacol Sci https://doi.org/10.1016/j.tips.2024.05.008
A2 Z1 Lack of Formyl-Peptide Receptor 1 Mitigates Atherosclerosis in Hyperlipidemic Mice Döring, Y.; Bender, A.; Soehnlein, O. 2024 Thromb Haemost https://doi.org/10.1055/s-0044-1787264
A2 A7 B1 Z1 Gasdermin D drives focal Crystalline Thrombotic Microangiopathy by accelerating Immunothrombosis and Necroinflammation Watanabe-Kusunoki, K.; Li, C.; Bandeira Honda, T. S.; Zhao, D.; Kusunoki, Y.; Ku, J.; Long, H.; Klaus, M.; Han, C.; Braun, A.; Mammadova-Bach, E.; Linkermann, A.; Van Avondt, K.; Richter, M.; Soehnlein, O.; Linder, M. I.; Klein, C.; Steiger, S.; Anders, H.-J. 2024 Blood https://doi.org/10.1182/blood.2023021949
A2 A3 C5 C6 Z1 Stroke and Myocardial Infarction Induce Neutrophil Extracellular Trap Release Disrupting Lymphoid Organ Structure and Immunoglobulin Secretion Tuz, A. A.; Ghosh, S.; Karsch, L.; Ttoouli, D.; Sata, S. P.; Ulusoy, Ö.; Kraus, A.; Hoerenbaum, N.; Wolf, J.-N.; Lohmann, S.; Zwirnlein, F.; Kaygusuz, V.; Lakovic, V.; Tummes, H.-L.; Beer, A.; Gallert, M.; Thiebes, S.; Qefalia, A.; Cibir, Z.; Antler, M.; Korste, S.; Haj Yehia, E.; Michel, L.; Rassaf, T.; Kaltwasser, B.; Abdelrahman, H.; Mohamud Yusuf, A.; Wang, C.; Yin, D.; Haeusler, L.; Lueong, S.; Richter, M.; Engel, D. R.; Stenzel, M.; Soehnlein, O.; Frank, B.; Solo-Nomenjanahary, M.; Ho-Tin-Noé, B.; Siveke, J. T.; Totzeck, M.; Hoffmann, D.; Grüneboom, A.; Hagemann, N.; Hasenberg, A.; Desilles, J.-P.; Mazighi, M.; Sickmann, A.; Chen, J.; Hermann, D. M.; Gunzer, M.; Singh, V. 2024 Nat Cardiovasc Res https://doi.org/10.1038/s44161-024-00462-8
A3 Z1 Scientific Advances in Understanding the Pathogenesis, Diagnosis, and Prevention of Urinary Tract Infection in the Past 10 Years Engel, D. R.; Wagenlehner, F. M. E.; Shevchuk, O. 2024 Infect Dis Clin North Am https://doi.org/10.1016/j.idc.2024.03.002
A2 Z1 Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease Soehnlein, O.; Döring, Y. 2023 European Heart Journal https://doi.org/10.1093/eurheartj/ehad711
A3 A5 Z1 Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infection Zec, K.; Thiebes, S.; Bottek, J.; Siemes, D.; Spangenberg, P.; Trieu, D. V.; Kirstein, N.; Subramaniam, N.; Christ, R.; Klein, D.; Jendrossek, V.; Loose, M.; Wagenlehner, F.; Jablonska, J.; Bracht, T.; Sitek, B.; Budeus, B.; Klein-Hitpass, L.; Theegarten, D.; Shevchuk, O.; Engel, D. R. 2023 Front Immunol https://doi.org/10.3389/fimmu.2023.1227191
Z1 Visualization of Metabolites and Microbes at High Spatial Resolution Using MALDI Mass Spectrometry Imaging and in Situ Fluorescence Labeling. Bourceau, P.; Geier, B.; Suerdieck, V.; Bien, T.; Soltwisch, J.; Dreisewerd, K.; Liebeke, M. 2023 Nat Protoc https://doi.org/10.1038/s41596-023-00864-1
A2 Z1 DRANquilizing neutrophil function in chronic liver disease Groba, S. R.; Soehnlein, O. 2023 J Hepatol https://doi.org/10.1016/j.jhep.2023.07.019
Z1 Visualization of Differential Cardiolipin Profiles in Murine Retinal Cell Layers by High-Resolution MALDI Mass Spectrometry Imaging Bessler, S.; Soltwisch, J.; Dreisewerd, K. 2023 Anal Chem https://doi.org/10.1021/acs.analchem.3c01465
A1 A2 C2 Z1 The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation Gatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K. 2023 Immunity https://doi.org/10.1016/j.immuni.2023.03.021
A3 C5 C6 Z1 Rapid and Fully Automated Blood Vasculature Analysis in 3D Light-Sheet Image Volumes of Different Organs Spangenberg, P.; Hagemann, N.; Squire, A.; Förster, N.; Krauß, S. D.; Qi, Y.; Yusuf, A. M.; Wang, J.; Grüneboom, A.; Kowitz, L.; Korste, S.; Totzeck, M.; Cibir, Z.; Tuz, A. A.; Singh, V.; Siemes, D.; Struensee, L.; Engel, D. R.; Ludewig, P.; Nascentes Melo, L. M.; Helfrich, I.; Chen, J.; Gunzer, M.; Hermann, D. M.; Mosig, A. 2023 Cell Reports Methods https://doi.org/10.1016/j.crmeth.2023.100436
A2 Z1 The Angiopoietin Receptor Tie2 Is Atheroprotective in Arterial Endothelium Anisimov, A.; Fang, S.; Hemanthakumar, K. A.; Örd, T.; van Avondt, K.; Chevre, R.; Toropainen, A.; Singha, P.; Gilani, H.; Nguyen, S. D.; Karaman, S.; Korhonen, E. A.; Adams, R. H.; Augustin, H. G.; Öörni, K.; Soehnlein, O.; Kaikkonen, M. U.; Alitalo, K. 2023 Nat Cardiovasc Res https://doi.org/10.1038/s44161-023-00224-y
A1 A2 Z1 Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic Mice Pan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O. 2023 Circulation https://doi.org/10.1161/CIRCULATIONAHA.122.063184
A2 Z1 Longitudinal in vivo monitoring of atheroprogression in hypercholesterolemic mice using photoacoustic imaging Ferraro, B.; Giustetto, P.; Schengel, O.; Weckbach, L.; Maegdefessel, L.; Soehnlein, O. 2023 Thromb Haemost https://doi.org/10.1055/a-2005-8784
A2 Z1 Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation Mauersberger, C.; Sager, H. B.; Wobst, J.; Dang, T. A.; Lambrecht, L.; Koplev, S.; Stroth, M.; Bettaga, N.; Schlossmann, J.; Wunder, F.; Friebe, A.; Björkegren, J. L. M.; Dietz, L.; Maas, S. L.; van der Vorst, E. P. C.; Sandner, P.; Soehnlein, O.; Schunkert, H.; Kessler, T. 2022 Nature Cardiovascular Research https://doi.org/10.1038/s44161-022-00175-w
A2 A6 E B2 Z1 Neutrophils in aging and aging-related pathologies Van Avondt, K.; Strecker, J.-K.; Tulotta, C.; Minnerup, J.; Schulz, C.; Soehnlein, O. 2022 Immunol Rev https://doi.org/10.1111/imr.13153
A2 Z1 AIMing 2 treat atherosclerosis Soehnlein, O.; Tall, A. R. 2022 Nat Rev Cardiol https://doi.org/10.1038/s41569-022-00755-0
A2 Z1 Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation Sohrabi, Y.; Reinecke, H.; Soehnlein, O. 2022 Signal Transduct Target Ther https://doi.org/10.1038/s41392-022-01121-9

Visualizing neutrophils in context

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