Emergency granulopoiesis generates immature neutrophil subpopulations as regulators of thromboinflammation
Neutrophils and platelets cooperate in immunosurveillance to safeguard host defence; yet, this interaction can become pathogenic. Here, we link neutrophil substates in thrombus development to functional states. Specifically, we map and isolate thrombus-resident neutrophil subsets and dissect their prothrombotic properties. We trace neutrophil maturation trajectories from the circulation towards and within thrombi. Finally, we use models of altered granulopoiesis to assess how different circulating neutrophil maturation states influence thromboinflammation.
Team
Publications
CCR2+ Neutrophils Exhibit a Proinflammatory Phenotype and Contribute to Plaque Vulnerability.Farjia, M.; Pan, C.; Braster, Q.; Lemnitzer, P.; Sachs, N.; Vöcking, L.-M.; Chevre, R.; Malamud, M.; Schulz, C.; Maegdefesel, L.; Soehnlein, O.; Silvestre-Roig, C.
2026 Arterioscler Thromb Vasc Biol
|
Divergent Granulopoiesis at Extramedullary Sites Safeguards Antibacterial Host DefenseSilvestre-Roig, C.; Chevre, R.; Farjia, M.; Bender, A.; Vöcking, L. M.; Richter, M.; Hageb, A.; Suerdieck, V.; Arenas Cerro, F. J.; Braster, Q.; Guzman, M.; Sintes, J.; Sharma, S.; Lemnitzer, P.; Tulotta, C.; Börgeling, Y.; Herrero-Cervera, A.; Flueter, H.; Reinartz Groba, S. N.; Ahern, D.; Osei-Sarpong, C.; Zimmer, R.; Alonso-Gonzalez, N.; Ortega, E.; Lienenklaus, S.; Kalinke, U.; Ludwig, S.; Engel, D. R.; Rosenbauer, F.; Monaco, C.; Dersch, P.; Kibler, A.; Cerutti, A.; Chavakis, T.; Benedito, R.; Hidalgo, A.; Jablonska, J.; Palomino-Segura, M.; Soehnlein, O.
2026 Sci Immunol
|
SARS-CoV-2 Peptide Fragments Selectively Dysregulate Specific Immune Cell Populations via Gaussian Curvature TargetingZhang, Y.; Silvestre-Roig, C.; Fu, H.; Alimohamadi, H.; Mandal, T.; Chen, J. W.; Luo, E. W.-C.; Anda, J. D.; Linard Matos, A. L.; Richter, M.; Mennella, A.; Lee, H.; Chan, L. C.; Wang, Y.; Wang, N.; Wang, H.; Wang, X.; Lee, C. K.; Ghosh, S.; Matsui, T.; Weiss, T. M.; Guo, T.; Zhang, M.; Li, D.; Wolfgang, M. C.; Hagan, R. S.; Li, M. M. H.; Gunzer, M.; Sickmann, A.; Frasca, L.; Yeaman, M. R.; Lande, R.; Cui, Q.; Soehnlein, O.; Wong, G. C. L.
2026 Proc Natl Acad Sci
|
The Nuclear Receptor NR4A1 Serves as a Neutrophil-Intrinsic Regulator Mitigating Stroke SeverityStrecker, J.-K.; Schmidt, Y.; Liebmann, M.; Walter, C.; Roth, S.; Aleth, H.; Börsch, A.-L.; Schmidt-Pogoda, A.; Beuker, C.; Yusuf, A. M.; Revenstorff, J.; Osei-Sarpong, C.; Krafft, L.; Schwarze, A.-S.; Heming, M.; Richter, M.; Kuhlmann, T.; Hucke, S.; Heming, J.-N.; Hansen, U.; Hagemann, N.; Bader, A.; Gao, J.; Walzog, B.; Maier-Begandt, D.; Chevre, R.; Hanschmann, E.-M.; Lücke, M.; Sommer, C.; Hermann, D. M.; Roth, J.; Thomas, C.; Meyer Zu Hörste, G.; Gunzer, M.; Vogl, T.; Zarbock, A.; Rosenbauer, F.; Silvestre-Roig, C.; Söhnlein, O.; Klotz, L.; Minnerup, J.
2025 bioRxiv
|
Neutrophil Progenitor Mobilization Is a Distinct Feature of STEMI and Predicts SurvivalRichter, M.; Von Göwels*, J.; Fähndrich*, M.; Fernandez*, C. L.; Grohn*, K.; Schwarz, D.; Lang, A.; Polzin, A.; Farinola, L.; Gosh, S.; Groba, S. R.; Heming, J.-N.; Aleth, H.; Rübsamen, N.; Radecke, T.; Rosenbauer, F.; Sickmann, A.; Karch, A.; Zarbock, A.; Minnerup, J.; Sindermann, J.; Bender, A.; Rossaint, J.; Ormanns, S.; Gunzer, M.; Reinecke, H.; Makowski, L.; Jung, C.; Silvestre-Roig, C.; Kelm, M.; Gerdes, N.; Chevre, R.; Lange, S.; Soehnlein, O.
2025 Research Square
|
Neutrophil-Specific Targeting of STAT3 Impairs Tumor Progression via the Expansion of Cytotoxic CD8+ T CellsOzel, I.; Sha, G.; Będzińska, A.; Pylaeva, E.; Naumova, Y.; Thiel, I.; Antczak, J.; Squire, A.; Gunzer, M.; Zelinskyy, G.; Kürten, C.; Lang, S.; Silvestre-Roig, C.; Kortylewski, M.; Granot, Z.; Jablonska, J.
2025 Signal Transduct Target Ther
|
Ontogenetic Drivers of Neutrophil HeterogeneityHageb, A.; Farjia, M.; Osei-Sarpong, C.; Silvestre-Roig, C.
2025 Exp Hematol
|
From complexity to consensus: A roadmap for neutrophil classificationNg, L. G.; Ballesteros, I.; Cassatella, M. A.; Egeblad, M.; Fridlender, Z. G.; Gabrilovich, D.; Gao, Q.; Granot, Z.; Grieshaber-Bouyer, R.; Grimes, H. L.; Hedrick, C. C.; Hidalgo, A.; Kaplan, M. J.; Kubes, P.; Ling, G. S.; Lu, L.; Luo, H. R.; Mayadas, T. N.; Moutsopoulos, N. M.; Ng, M.; Nigrovic, P. A.; Ostuni, R.; Pittet, M. J.; Quail, D. F.; Silvestre-Roig, C.; Soehnlein, O.; Udalova, I. A.; Xue, R.; Zhang, N.; Kwok, I.
2025 Immunity
|
Novel Possibilities for Targeting Neutrophils in CancerSilvestre-Roig, C.; Kalafati, L.; Chavakis, T.
2024 Sig Transduct Target Ther
|
Controversies associated with the identification of the true origins of human neutrophilsSilvestre-Roig, C.; Brandau, S.
2024 Journal of Leukocyte Biology
|
The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammationGatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.
2023 Immunity
|
Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic MicePan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O.
2023 Circulation
|