Organ-specific priming during granulopoiesis generates neutrophil subsets
Neutrophils are traditionally been looked upon as a homogenous population of short-lived, end-differentiated, and transcriptionally silent leukocytes. In this project, we will develop a concept of neutrophil heterogeneity based on the organ-dependent specification of neutrophil progenitors to differentiate into distinct neutrophil lineages. Multi-omics analyses and functional studies will reveal the contribution of splenic and bone marrow neutrophils to regulation of the immune response and tissue damage during inflammation.
Team
Publications
Novel Possibilities for Targeting Neutrophils in CancerSilvestre-Roig, C.; Kalafati, L.; Chavakis, T.
2024 Sig Transduct Target Ther
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Controversies associated with the identification of the true origins of human neutrophilsSilvestre-Roig, C.; Brandau, S.
2024 Journal of Leukocyte Biology
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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammationGatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.
2023 Immunity
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Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic MicePan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O.
2023 Circulation
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