A1

Emergency granulopoiesis generates immature neutrophil subpopulations as regulators of thromboinflammation

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Neutrophils and platelets cooperate in immunosurveillance to safeguard host defence; yet, this interaction can become pathogenic. Here, we link neutrophil substates in thrombus development to functional states. Specifically, we map and isolate thrombus-resident neutrophil subsets and dissect their prothrombotic properties. We trace neutrophil maturation trajectories from the circulation towards and within thrombi. Finally, we use models of altered granulopoiesis to assess how different circulating neutrophil maturation states influence thromboinflammation.

Team

Publications

Divergent Granulopoiesis at Extramedullary Sites Safeguards Antibacterial Host Defense

Silvestre-Roig, C.; Chevre, R.; Farjia, M.; Bender, A.; Vöcking, L. M.; Richter, M.; Hageb, A.; Suerdieck, V.; Arenas Cerro, F. J.; Braster, Q.; Guzman, M.; Sintes, J.; Sharma, S.; Lemnitzer, P.; Tulotta, C.; Börgeling, Y.; Herrero-Cervera, A.; Flueter, H.; Reinartz Groba, S. N.; Ahern, D.; Osei-Sarpong, C.; Zimmer, R.; Alonso-Gonzalez, N.; Ortega, E.; Lienenklaus, S.; Kalinke, U.; Ludwig, S.; Engel, D. R.; Rosenbauer, F.; Monaco, C.; Dersch, P.; Kibler, A.; Cerutti, A.; Chavakis, T.; Benedito, R.; Hidalgo, A.; Jablonska, J.; Palomino-Segura, M.; Soehnlein, O.

2026 Sci Immunol

SARS-CoV-2 Peptide Fragments Selectively Dysregulate Specific Immune Cell Populations via Gaussian Curvature Targeting

Zhang, Y.; Silvestre-Roig, C.; Fu, H.; Alimohamadi, H.; Mandal, T.; Chen, J. W.; Luo, E. W.-C.; Anda, J. D.; Linard Matos, A. L.; Richter, M.; Mennella, A.; Lee, H.; Chan, L. C.; Wang, Y.; Wang, N.; Wang, H.; Wang, X.; Lee, C. K.; Ghosh, S.; Matsui, T.; Weiss, T. M.; Guo, T.; Zhang, M.; Li, D.; Wolfgang, M. C.; Hagan, R. S.; Li, M. M. H.; Gunzer, M.; Sickmann, A.; Frasca, L.; Yeaman, M. R.; Lande, R.; Cui, Q.; Soehnlein, O.; Wong, G. C. L.

2026 Proc Natl Acad Sci

The Nuclear Receptor NR4A1 Serves as a Neutrophil-Intrinsic Regulator Mitigating Stroke Severity

Strecker, J.-K.; Schmidt, Y.; Liebmann, M.; Walter, C.; Roth, S.; Aleth, H.; Börsch, A.-L.; Schmidt-Pogoda, A.; Beuker, C.; Yusuf, A. M.; Revenstorff, J.; Osei-Sarpong, C.; Krafft, L.; Schwarze, A.-S.; Heming, M.; Richter, M.; Kuhlmann, T.; Hucke, S.; Heming, J.-N.; Hansen, U.; Hagemann, N.; Bader, A.; Gao, J.; Walzog, B.; Maier-Begandt, D.; Chevre, R.; Hanschmann, E.-M.; Lücke, M.; Sommer, C.; Hermann, D. M.; Roth, J.; Thomas, C.; Meyer Zu Hörste, G.; Gunzer, M.; Vogl, T.; Zarbock, A.; Rosenbauer, F.; Silvestre-Roig, C.; Söhnlein, O.; Klotz, L.; Minnerup, J.

2025 bioRxiv

Neutrophil Progenitor Mobilization Is a Distinct Feature of STEMI and Predicts Survival

Richter, M.; Von Göwels*, J.; Fähndrich*, M.; Fernandez*, C. L.; Grohn*, K.; Schwarz, D.; Lang, A.; Polzin, A.; Farinola, L.; Gosh, S.; Groba, S. R.; Heming, J.-N.; Aleth, H.; Rübsamen, N.; Radecke, T.; Rosenbauer, F.; Sickmann, A.; Karch, A.; Zarbock, A.; Minnerup, J.; Sindermann, J.; Bender, A.; Rossaint, J.; Ormanns, S.; Gunzer, M.; Reinecke, H.; Makowski, L.; Jung, C.; Silvestre-Roig, C.; Kelm, M.; Gerdes, N.; Chevre, R.; Lange, S.; Soehnlein, O.

2025 Research Square

From complexity to consensus: A roadmap for neutrophil classification

Ng, L. G.; Ballesteros, I.; Cassatella, M. A.; Egeblad, M.; Fridlender, Z. G.; Gabrilovich, D.; Gao, Q.; Granot, Z.; Grieshaber-Bouyer, R.; Grimes, H. L.; Hedrick, C. C.; Hidalgo, A.; Kaplan, M. J.; Kubes, P.; Ling, G. S.; Lu, L.; Luo, H. R.; Mayadas, T. N.; Moutsopoulos, N. M.; Ng, M.; Nigrovic, P. A.; Ostuni, R.; Pittet, M. J.; Quail, D. F.; Silvestre-Roig, C.; Soehnlein, O.; Udalova, I. A.; Xue, R.; Zhang, N.; Kwok, I.

2025 Immunity

The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

Gatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.

2023 Immunity