Organ-specific priming during granulopoiesis generates neutrophil subsets
Neutrophils are traditionally been looked upon as a homogenous population of short-lived, end-differentiated, and transcriptionally silent leukocytes. In this project, we will develop a concept of neutrophil heterogeneity based on the organ-dependent specification of neutrophil progenitors to differentiate into distinct neutrophil lineages. Multi-omics analyses and functional studies will reveal the contribution of splenic and bone marrow neutrophils to regulation of the immune response and tissue damage during inflammation.
Team
Publications
Divergent Granulopoiesis at Extramedullary Sites Safeguards Antibacterial Host DefenseSilvestre-Roig, C.; Chevre, R.; Farjia, M.; Bender, A.; Vöcking, L. M.; Richter, M.; Hageb, A.; Suerdieck, V.; Arenas Cerro, F. J.; Braster, Q.; Guzman, M.; Sintes, J.; Sharma, S.; Lemnitzer, P.; Tulotta, C.; Börgeling, Y.; Herrero-Cervera, A.; Flueter, H.; Reinartz Groba, S. N.; Ahern, D.; Osei-Sarpong, C.; Zimmer, R.; Alonso-Gonzalez, N.; Ortega, E.; Lienenklaus, S.; Kalinke, U.; Ludwig, S.; Engel, D. R.; Rosenbauer, F.; Monaco, C.; Dersch, P.; Kibler, A.; Cerutti, A.; Chavakis, T.; Benedito, R.; Hidalgo, A.; Jablonska, J.; Palomino-Segura, M.; Soehnlein, O.
2026 Sci Immunol
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SARS-CoV-2 Peptide Fragments Selectively Dysregulate Specific Immune Cell Populations via Gaussian Curvature TargetingZhang, Y.; Silvestre-Roig, C.; Fu, H.; Alimohamadi, H.; Mandal, T.; Chen, J. W.; Luo, E. W.-C.; Anda, J. D.; Linard Matos, A. L.; Richter, M.; Mennella, A.; Lee, H.; Chan, L. C.; Wang, Y.; Wang, N.; Wang, H.; Wang, X.; Lee, C. K.; Ghosh, S.; Matsui, T.; Weiss, T. M.; Guo, T.; Zhang, M.; Li, D.; Wolfgang, M. C.; Hagan, R. S.; Li, M. M. H.; Gunzer, M.; Sickmann, A.; Frasca, L.; Yeaman, M. R.; Lande, R.; Cui, Q.; Soehnlein, O.; Wong, G. C. L.
2026 Proc Natl Acad Sci
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The Nuclear Receptor NR4A1 Serves as a Neutrophil-Intrinsic Regulator Mitigating Stroke SeverityStrecker, J.-K.; Schmidt, Y.; Liebmann, M.; Walter, C.; Roth, S.; Aleth, H.; Börsch, A.-L.; Schmidt-Pogoda, A.; Beuker, C.; Yusuf, A. M.; Revenstorff, J.; Osei-Sarpong, C.; Krafft, L.; Schwarze, A.-S.; Heming, M.; Richter, M.; Kuhlmann, T.; Hucke, S.; Heming, J.-N.; Hansen, U.; Hagemann, N.; Bader, A.; Gao, J.; Walzog, B.; Maier-Begandt, D.; Chevre, R.; Hanschmann, E.-M.; Lücke, M.; Sommer, C.; Hermann, D. M.; Roth, J.; Thomas, C.; Meyer Zu Hörste, G.; Gunzer, M.; Vogl, T.; Zarbock, A.; Rosenbauer, F.; Silvestre-Roig, C.; Söhnlein, O.; Klotz, L.; Minnerup, J.
2025 bioRxiv
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Neutrophil Progenitor Mobilization Is a Distinct Feature of STEMI and Predicts SurvivalRichter, M.; Von Göwels*, J.; Fähndrich*, M.; Fernandez*, C. L.; Grohn*, K.; Schwarz, D.; Lang, A.; Polzin, A.; Farinola, L.; Gosh, S.; Groba, S. R.; Heming, J.-N.; Aleth, H.; Rübsamen, N.; Radecke, T.; Rosenbauer, F.; Sickmann, A.; Karch, A.; Zarbock, A.; Minnerup, J.; Sindermann, J.; Bender, A.; Rossaint, J.; Ormanns, S.; Gunzer, M.; Reinecke, H.; Makowski, L.; Jung, C.; Silvestre-Roig, C.; Kelm, M.; Gerdes, N.; Chevre, R.; Lange, S.; Soehnlein, O.
2025 Research Square
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Divergent Granulopoiesis at Extramedullary Sites Safeguards Host DefenseSilvestre-Roig, C.; Chevre, R.; Bender, A.; Vöcking, L. M.; Hageb, A.; Richter, M.; Farjia, M.; Braster, Q.; Guzman, M.; Sintes, J.; Sharma, S.; Lemnitzer, P.; Ahern, D.; Osei-Sarpong, C.; Engel, D. R.; Monaco, C.; Dersch, P.; Kibler, A.; Cerutti, A.; Chavakis, T.; Jablonska, J.; Soehnlein, O.
2025 bioRxiv
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CCR2+ Neutrophils Exhibit a Proinflammatory Phenotype and Promote Plaque DestabilizationFarjia, M.; Pan, C.; Braster, Q.; Lemnitzer, P.; Sachs, N.; Schulz, C.; Maegdefesel, L.; Soehnlein, O.; Silvestre-Roig, C.
2025 bioRxiv
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Neutrophil-Specific Targeting of STAT3 Impairs Tumor Progression via the Expansion of Cytotoxic CD8+ T CellsOzel, I.; Sha, G.; Będzińska, A.; Pylaeva, E.; Naumova, Y.; Thiel, I.; Antczak, J.; Squire, A.; Gunzer, M.; Zelinskyy, G.; Kürten, C.; Lang, S.; Silvestre-Roig, C.; Kortylewski, M.; Granot, Z.; Jablonska, J.
2025 Signal Transduct Target Ther
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Ontogenetic Drivers of Neutrophil HeterogeneityHageb, A.; Farjia, M.; Osei-Sarpong, C.; Silvestre-Roig, C.
2025 Exp Hematol
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From complexity to consensus: A roadmap for neutrophil classificationNg, L. G.; Ballesteros, I.; Cassatella, M. A.; Egeblad, M.; Fridlender, Z. G.; Gabrilovich, D.; Gao, Q.; Granot, Z.; Grieshaber-Bouyer, R.; Grimes, H. L.; Hedrick, C. C.; Hidalgo, A.; Kaplan, M. J.; Kubes, P.; Ling, G. S.; Lu, L.; Luo, H. R.; Mayadas, T. N.; Moutsopoulos, N. M.; Ng, M.; Nigrovic, P. A.; Ostuni, R.; Pittet, M. J.; Quail, D. F.; Silvestre-Roig, C.; Soehnlein, O.; Udalova, I. A.; Xue, R.; Zhang, N.; Kwok, I.
2025 Immunity
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Novel Possibilities for Targeting Neutrophils in CancerSilvestre-Roig, C.; Kalafati, L.; Chavakis, T.
2024 Sig Transduct Target Ther
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Controversies associated with the identification of the true origins of human neutrophilsSilvestre-Roig, C.; Brandau, S.
2024 Journal of Leukocyte Biology
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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammationGatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.
2023 Immunity
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Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic MicePan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O.
2023 Circulation
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